Replication of herpesvirus DNA. III. Rate of DNA elongation
نویسندگان
چکیده
منابع مشابه
Herpesvirus DNA Replication
The genomes of herpesviruses are linear double-stranded DNA molecules ranging in size from 120 kb to more than 200 kb. Although the many different herpesviruses display a wide variety of tissue tropisms and vary enormously in the way in which they interact with their natural hosts, one common feature of the biology of all herpesviruses is the mechanism by which they replicate their genomes duri...
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DNA replication is highly regulated in most organisms. Although much research has focused on mechanisms that regulate initiation of replication, mechanisms that regulate elongation of replication are less well understood. We characterized a mechanism that regulates replication elongation in the bacterium Bacillus subtilis. Replication elongation was inhibited within minutes after amino acid sta...
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Bacteriophage PRD1 replicates its DNA by means of a protein-primed replication mechanism. Compared to Mg2+, the use of Mn2+ as the metal activator of the phage DNA polymerase results in a great stimulation of the initiation reaction. The molecular basis of the observed stimulatory effect is an increase in the velocity of the reaction. The phage DNA polymerase is also able to catalyze the format...
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The influence of d(G)n.d(C)n repeats on plasmid replication in Escherichia coli cells was analyzed using electrophoretic analysis of replication intermediates. These repeats impeded the replication fork in a length- and orientation-dependent manner. Unexpectedly, the replication arrest relied primarily on the repeats' transcription. When the d(C)n sequence served as the transcriptional template...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1977
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.22.3.734-741.1977